A Novel Murine Pneumonia and Bacteremia Model for Carbapenem-Resistant Klebsiella pneumoniae Infection

Background: The incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections has increased significantly in recent years, posing a major public health threat. Invasive CRKP infections may retain in vitro susceptibility only to second-line agents such as tigecycline and polymyxins, with mortality as high as 58% in some series. Present clinical data has relied principally on retrospective studies.

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